Arizona Cardinals at San Francisco 49ers
| Team | 1 | 2 | 3 | 4 | Score | Status |
| Arizona Cardinals | 0 | 3 | 3 | 9 | 15 | |
| San Francisco 49ers | 0 | 6 | 0 | 10 | 16 | Final |
| Scoring Summary | |
| 2nd Quarter | |
| 8:45 | Arizona Cardinals field goal. Chad Ryland 34 Yd Field Goal |
| 4:22 | San Francisco 49ers field goal. Eddy Pineiro 38 Yd Field Goal |
| 0:17 | San Francisco 49ers field goal. Eddy Pineiro 51 Yd Field Goal |
| 3rd Quarter | |
| 6:37 | Arizona Cardinals field goal. Chad Ryland 28 Yd Field Goal |
| 4th Quarter | |
| 10:50 | San Francisco 49ers touchdown. Kyle Juszczyk 1 Yd pass from Mac Jones (Eddy Pineiro Kick) |
| 8:37 | Arizona Cardinals touchdown. Trey McBride 1 Yd pass from Kyler Murray (Chad Ryland Kick) |
| 3:15 | Arizona Cardinals safety. Defensive Holding in Endzone for Safety |
| 0:00 | San Francisco 49ers field goal. Eddy Pineiro 35 Yd Field Goal |
| Team stats | ||
| First down | Arizona Cardinals | San Francisco 49ers |
| Total first downs | 16 | 19 |
| First downs from rushing | 7 | 4 |
| First downs from passing | 8 | 14 |
| First downs from penalties | 1 | 1 |
| Third down | Arizona Cardinals | San Francisco 49ers |
| Third downs attempted | 15 | 10 |
| Third downs converted | 5 | 2 |
| Third down percentage | 33 % | 20 % |
| Fourth down | Arizona Cardinals | San Francisco 49ers |
| Fourth downs attempted | 0 | 0 |
| Fourth downs converted | 0 | 0 |
| Fourth down percentage | 0 % | 0 % |
| Offense | Arizona Cardinals | San Francisco 49ers |
| Total yards | 260 | 355 |
| Total rushing yards | 106 | 73 |
| Total passing yards | 154 | 282 |
| Total offensive plays | 64 | 62 |
| Average yards per play | 4.1 | 5.7 |
| Time of possession | 34:39 | 25:21 |
| Rushing | Arizona Cardinals | San Francisco 49ers |
| Total rushing plays | 28 | 20 |
| Total rushing yards | 106 | 73 |
| Average yards per rush | 3.8 | 3.7 |
| Rushing touchdowns | 0 | 0 |
| Passing | Arizona Cardinals | San Francisco 49ers |
| Passes attempted | 0 | 0 |
| Passes completed | 0 | 0 |
| Average yards per completion | 4.3 | 6.7 |
| Passing touchdowns | 1 | 1 |
| Penalties | Arizona Cardinals | San Francisco 49ers |
| Penalties committed | 5 | 5 |
| Penalty yards | 30 | 69 |
| Turnovers | Arizona Cardinals | San Francisco 49ers |
| Passes intercepted | 0 | 1 |
| Interception returns | 0 | 1 |
| Interception return yards | ||
| Fumbles | ||
| Fumbles lost | 0 | 0 |
| Rushing | |||||||||
| Arizona Cardinals | Rushes | Yards | Yards/rush | TD | Long | ||||
| Trey Benson | 10 | 42 | 4.2 | 0 | 29 | ||||
| Kyler Murray | 6 | 37 | 6.2 | 0 | 9 | ||||
| James Conner | 9 | 22 | 2.4 | 0 | 9 | ||||
| Greg Dortch | 1 | 5 | 5.0 | 0 | 5 | ||||
| Emari Demercado | 2 | 0 | 0.0 | 0 | 1 | ||||
| San Francisco 49ers | Rushes | Yards | Yards/rush | TD | Long | ||||
| Christian McCaffrey | 17 | 52 | 3.1 | 0 | 15 | ||||
| Brian Robinson Jr. | 2 | 22 | 11.0 | 0 | 19 | ||||
| Mac Jones | 1 | -1 | -1.0 | 0 | -1 | ||||
| Passing | |||||||||
| Arizona Cardinals | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Kyler Murray | 35 | 22 | 63 % | 159 | 4.5 | 1 | 0 | 1-5 | 54.7 |
| San Francisco 49ers | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Mac Jones | 41 | 27 | 66 % | 284 | 6.9 | 1 | 1 | 1-2 | 65.4 |
| Receiving | |||||||||
| Arizona Cardinals | Catches | Yards | Yards/catch | TD | Long | ||||
| Marvin Harrison Jr. | 3 | 44 | 14.7 | 0 | 32 | ||||
| Trey McBride | 5 | 43 | 8.6 | 1 | 17 | ||||
| Zay Jones | 2 | 25 | 12.5 | 0 | 18 | ||||
| James Conner | 3 | 15 | 5.0 | 0 | 10 | ||||
| Trey Benson | 3 | 9 | 3.0 | 0 | 5 | ||||
| Tip Reiman | 2 | 8 | 4.0 | 0 | 6 | ||||
| Elijah Higgins | 1 | 7 | 7.0 | 0 | 7 | ||||
| Michael Wilson | 1 | 5 | 5.0 | 0 | 5 | ||||
| Greg Dortch | 2 | 3 | 1.5 | 0 | 2 | ||||
| Emari Demercado | 0 | 0 | 0.0 | 0 | 0 | ||||
| San Francisco 49ers | Catches | Yards | Yards/catch | TD | Long | ||||
| Ricky Pearsall | 8 | 117 | 14.6 | 0 | 34 | ||||
| Christian McCaffrey | 10 | 88 | 8.8 | 0 | 20 | ||||
| Kendrick Bourne | 4 | 38 | 9.5 | 0 | 11 | ||||
| Jake Tonges | 2 | 21 | 10.5 | 0 | 11 | ||||
| Skyy Moore | 1 | 10 | 10.0 | 0 | 10 | ||||
| Marquez Valdes-Scantling | 1 | 9 | 9.0 | 0 | 9 | ||||
| Kyle Juszczyk | 1 | 1 | 1.0 | 1 | 1 | ||||
| Fumbles | |||||||||
| Arizona Cardinals | Lost | Recovered | Total | ||||||
| James Conner | 0 | 0 | 1 | ||||||
| Hjalte Froholdt | 0 | 1 | 0 | ||||||
| San Francisco 49ers | Lost | Recovered | Total | ||||||
| None | |||||||||
| Interceptions | |||||||||
| Arizona Cardinals | Total | Yards | Int TDs | ||||||
| Dadrion Taylor-Demerson | 1 | 18 | 0 | ||||||
| San Francisco 49ers | Total | Yards | Int TDs | ||||||
| None | |||||||||
| Defense | |||||||||
| Arizona Cardinals | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Mack Wilson Sr. | 12 | 6 | 1 | 2 | 0 | 0 | 0 | 0 | |
| Akeem Davis-Gaither | 8 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jalen Thompson | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Budda Baker | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kei'Trel Clark | 5 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Dadrion Taylor-Demerson | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Dalvin Tomlinson | 3 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Max Melton | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Denzel Burke | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Josh Sweat | 2 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | |
| Kitan Crawford | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Zaven Collins | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Cody Simon | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Calais Campbell | 1 | 1 | 0 | 0 | 3 | 0 | 0 | 0 | |
| Simi Fehoko | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| PJ Mustipher | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Jordan Burch | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Darius Robinson | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Baron Browning | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Dante Stills | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Anthony Goodlow | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Owen Pappoe | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| San Francisco 49ers | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Fred Warner | 11 | 5 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Dee Winters | 8 | 4 | 0 | 1 | 1 | 0 | 0 | 0 | |
| Sam Okuayinonu | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Marques Sigle | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Upton Stout | 5 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Bryce Huff | 5 | 2 | 1 | 1 | 2 | 0 | 0 | 0 | |
| Ji'Ayir Brown | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Renardo Green | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jason Pinnock | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Deommodore Lenoir | 3 | 3 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Jordan Elliott | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Mykel Williams | 2 | 2 | 1 | 0 | 1 | 0 | 0 | 0 | |
| CJ West | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Luke Gifford | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Nick Bosa | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kalia Davis | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Darrell Luter Jr. | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Trent Williams | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Chase Lucas | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tatum Bethune | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Siran Neal | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Brayden Willis | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kick returns | |||||||||
| Arizona Cardinals | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| Greg Dortch | 2 | 58 | 29.0 | 33 | 0 | ||||
| Emari Demercado | 2 | 57 | 28.5 | 36 | 0 | ||||
| San Francisco 49ers | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| Skyy Moore | 2 | 61 | 30.5 | 31 | 0 | ||||
| Isaac Guerendo | 1 | 19 | 19.0 | 19 | 0 | ||||
| Punt returns | |||||||||
| Arizona Cardinals | Total | Yards | Avg | Long | TD | ||||
| Greg Dortch | 1 | 8 | 8.0 | 8 | 0 | ||||
| San Francisco 49ers | Total | Yards | Avg | Long | TD | ||||
| Skyy Moore | 3 | 26 | 8.7 | 14 | 0 | ||||
| Kicking | |||||||||
| Arizona Cardinals | FG | Long | Extra Pt | Points | |||||
| Chad Ryland | 2/3 | 34 | 1/1 | 7 | |||||
| San Francisco 49ers | FG | Long | Extra Pt | Points | |||||
| Eddy Pineiro | 3/3 | 51 | 1/1 | 10 | |||||
| Punting | |||||||||
| Arizona Cardinals | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Blake Gillikin | 5 | 258 | 51.6 | 1 | 2 | 55 | |||
| San Francisco 49ers | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Thomas Morstead | 3 | 128 | 42.7 | 0 | 2 | 48 | |||
Last updated on Wednesday, September 24, 2025 6:57 AM.