San Francisco 49ers at Indianapolis Colts
| Team | 1 | 2 | 3 | 4 | Score | Status |
| San Francisco 49ers | 14 | 10 | 10 | 14 | 48 | |
| Indianapolis Colts | 7 | 10 | 3 | 7 | 27 | Final |
| Scoring Summary | |
| 1st Quarter | |
| 10:31 | Indianapolis Colts touchdown. Alec Pierce 20 Yd pass from Philip Rivers (Blake Grupe Kick) |
| 7:14 | San Francisco 49ers touchdown. Demarcus Robinson 22 Yd pass from Brock Purdy (Eddy Pineiro Kick) |
| 4:33 | San Francisco 49ers touchdown. Christian McCaffrey 2 Yd pass from Brock Purdy (Eddy Pineiro Kick) |
| 2nd Quarter | |
| 14:15 | Indianapolis Colts touchdown. Alec Pierce 16 Yd pass from Philip Rivers (Blake Grupe Kick) |
| 9:36 | San Francisco 49ers touchdown. George Kittle 11 Yd pass from Brock Purdy (Eddy Pineiro Kick) |
| 1:51 | San Francisco 49ers field goal. Eddy Pineiro 25 Yd Field Goal |
| 0:17 | Indianapolis Colts field goal. Blake Grupe 39 Yd Field Goal |
| 3rd Quarter | |
| 10:58 | San Francisco 49ers touchdown. Jauan Jennings 3 Yd pass from Brock Purdy (Eddy Pineiro Kick) |
| 8:16 | Indianapolis Colts field goal. Blake Grupe 51 Yd Field Goal |
| 4:02 | San Francisco 49ers field goal. Eddy Pineiro 38 Yd Field Goal |
| 4th Quarter | |
| 12:41 | Indianapolis Colts touchdown. Jonathan Taylor 1 Yd Rush (Blake Grupe Kick) |
| 7:37 | San Francisco 49ers touchdown. Christian McCaffrey 9 Yd pass from Brock Purdy (Eddy Pineiro Kick) |
| 3:26 | San Francisco 49ers touchdown. Dee Winters 74 Yd Interception Return (Eddy Pineiro Kick) |
| Team stats | ||
| First down | San Francisco 49ers | Indianapolis Colts |
| Total first downs | 28 | 19 |
| First downs from rushing | 8 | 4 |
| First downs from passing | 20 | 13 |
| First downs from penalties | 0 | 2 |
| Third down | San Francisco 49ers | Indianapolis Colts |
| Third downs attempted | 11 | 10 |
| Third downs converted | 7 | 5 |
| Third down percentage | 64 % | 50 % |
| Fourth down | San Francisco 49ers | Indianapolis Colts |
| Fourth downs attempted | 0 | 0 |
| Fourth downs converted | 0 | 0 |
| Fourth down percentage | 0 % | 0 % |
| Offense | San Francisco 49ers | Indianapolis Colts |
| Total yards | 440 | 312 |
| Total rushing yards | 145 | 58 |
| Total passing yards | 295 | 254 |
| Total offensive plays | 66 | 58 |
| Average yards per play | 6.7 | 5.4 |
| Time of possession | 33:05 | 26:55 |
| Rushing | San Francisco 49ers | Indianapolis Colts |
| Total rushing plays | 31 | 20 |
| Total rushing yards | 145 | 58 |
| Average yards per rush | 4.7 | 2.9 |
| Rushing touchdowns | 0 | 1 |
| Passing | San Francisco 49ers | Indianapolis Colts |
| Passes attempted | 0 | 0 |
| Passes completed | 0 | 0 |
| Average yards per completion | 8.4 | 6.7 |
| Passing touchdowns | 5 | 2 |
| Penalties | San Francisco 49ers | Indianapolis Colts |
| Penalties committed | 2 | 6 |
| Penalty yards | 36 | 45 |
| Turnovers | San Francisco 49ers | Indianapolis Colts |
| Passes intercepted | 1 | 1 |
| Interception returns | 1 | 1 |
| Interception return yards | ||
| Fumbles | ||
| Fumbles lost | 0 | 1 |
| Rushing | |||||||||
| San Francisco 49ers | Rushes | Yards | Yards/rush | TD | Long | ||||
| Christian McCaffrey | 21 | 117 | 5.6 | 0 | 24 | ||||
| Brian Robinson Jr. | 5 | 20 | 4.0 | 0 | 11 | ||||
| Brock Purdy | 2 | 11 | 5.5 | 0 | 9 | ||||
| Mac Jones | 3 | -3 | -1.0 | 0 | -1 | ||||
| Indianapolis Colts | Rushes | Yards | Yards/rush | TD | Long | ||||
| Jonathan Taylor | 16 | 46 | 2.9 | 1 | 7 | ||||
| Tyler Goodson | 3 | 9 | 3.0 | 0 | 6 | ||||
| Josh Downs | 1 | 3 | 3.0 | 0 | 3 | ||||
| Passing | |||||||||
| San Francisco 49ers | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Brock Purdy | 34 | 25 | 74 % | 295 | 8.7 | 5 | 1 | 1-0 | 89.5 |
| Indianapolis Colts | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Philip Rivers | 35 | 23 | 66 % | 277 | 7.9 | 2 | 1 | 2-23 | 53.0 |
| Riley Leonard | 1 | 0 | 0 % | 0 | 0.0 | 0 | 0 | 0-0 | 2.3 |
| Receiving | |||||||||
| San Francisco 49ers | Catches | Yards | Yards/catch | TD | Long | ||||
| George Kittle | 7 | 115 | 16.4 | 1 | 26 | ||||
| Jauan Jennings | 5 | 71 | 14.2 | 1 | 21 | ||||
| Christian McCaffrey | 6 | 29 | 4.8 | 2 | 10 | ||||
| Kendrick Bourne | 3 | 27 | 9.0 | 0 | 14 | ||||
| Demarcus Robinson | 2 | 23 | 11.5 | 1 | 22 | ||||
| Skyy Moore | 1 | 23 | 23.0 | 0 | 23 | ||||
| Jake Tonges | 1 | 7 | 7.0 | 0 | 7 | ||||
| Brian Robinson Jr. | 0 | 0 | 0.0 | 0 | 0 | ||||
| Indianapolis Colts | Catches | Yards | Yards/catch | TD | Long | ||||
| Alec Pierce | 4 | 86 | 21.5 | 2 | 33 | ||||
| Josh Downs | 5 | 65 | 13.0 | 0 | 18 | ||||
| Jonathan Taylor | 3 | 33 | 11.0 | 0 | 19 | ||||
| Michael Pittman Jr. | 4 | 32 | 8.0 | 0 | 14 | ||||
| Tyler Warren | 3 | 30 | 10.0 | 0 | 19 | ||||
| Mo Alie-Cox | 2 | 16 | 8.0 | 0 | 8 | ||||
| Drew Ogletree | 1 | 11 | 11.0 | 0 | 11 | ||||
| Ameer Abdullah | 1 | 4 | 4.0 | 0 | 4 | ||||
| Coleman Owen | 0 | 0 | 0.0 | 0 | 0 | ||||
| Fumbles | |||||||||
| San Francisco 49ers | Lost | Recovered | Total | ||||||
| Brock Purdy | 0 | 0 | 1 | ||||||
| Luke Farrell | 0 | 1 | 0 | ||||||
| Jake Tonges | 0 | 1 | 0 | ||||||
| Indianapolis Colts | Lost | Recovered | Total | ||||||
| Ameer Abdullah | 1 | 0 | 1 | ||||||
| Philip Rivers | 0 | 0 | 1 | ||||||
| Danny Pinter | 0 | 1 | 0 | ||||||
| Interceptions | |||||||||
| San Francisco 49ers | Total | Yards | Int TDs | ||||||
| Dee Winters | 1 | 74 | 1 | ||||||
| Indianapolis Colts | Total | Yards | Int TDs | ||||||
| Cam Bynum | 1 | 8 | 0 | ||||||
| Defense | |||||||||
| San Francisco 49ers | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Ji'Ayir Brown | 9 | 5 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Tatum Bethune | 9 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Malik Mustapha | 8 | 3 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Darrell Luter Jr. | 6 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Upton Stout | 6 | 3 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Deommodore Lenoir | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Keion White | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Dee Winters | 3 | 1 | 0 | 2 | 0 | 1 | 0 | 0 | |
| Sam Okuayinonu | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kalia Davis | 3 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Jake Tonges | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Alfred Collins | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Bryce Huff | 2 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Eric Kendricks | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Luke Gifford | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| C.J. West | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Eli Apple | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Clelin Ferrell | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Marques Sigle | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Indianapolis Colts | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Cam Bynum | 7 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Germaine Pratt | 6 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Nick Cross | 6 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| DeForest Buckner | 5 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Cameron Mitchell | 4 | 4 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Samson Ebukam | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Zaire Franklin | 4 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Laiatu Latu | 3 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Neville Gallimore | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Mekhi Blackmon | 3 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | |
| George Odum | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kenny Moore II | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Johnathan Edwards | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Grover Stewart | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kwity Paye | 2 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Austin Ajiake | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ameer Abdullah | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Eric Johnson II | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Segun Olubi | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tyler Goodson | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Luke Rhodes | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tyquan Lewis | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jaylon Jones | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Kick returns | |||||||||
| San Francisco 49ers | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| Skyy Moore | 4 | 112 | 28.0 | 36 | 0 | ||||
| Brian Robinson Jr. | 2 | 55 | 27.5 | 31 | 0 | ||||
| Indianapolis Colts | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| Coleman Owen | 3 | 89 | 29.7 | 33 | 0 | ||||
| Tyler Goodson | 2 | 60 | 30.0 | 31 | 0 | ||||
| Ameer Abdullah | 1 | 17 | 17.0 | 17 | 0 | ||||
| Punt returns | |||||||||
| San Francisco 49ers | Total | Yards | Avg | Long | TD | ||||
| Skyy Moore | 1 | 8 | 8.0 | 8 | 0 | ||||
| Indianapolis Colts | Total | Yards | Avg | Long | TD | ||||
| None | |||||||||
| Kicking | |||||||||
| San Francisco 49ers | FG | Long | Extra Pt | Points | |||||
| Eddy Pineiro | 2/3 | 38 | 6/6 | 12 | |||||
| Indianapolis Colts | FG | Long | Extra Pt | Points | |||||
| Blake Grupe | 2/2 | 51 | 3/3 | 9 | |||||
| Punting | |||||||||
| San Francisco 49ers | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| None | |||||||||
| Indianapolis Colts | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Rigoberto Sanchez | 2 | 101 | 50.5 | 0 | 1 | 54 | |||
Last updated on Wednesday, December 24, 2025 7:11 PM.