Buffalo Bills at Carolina Panthers
| Team | 1 | 2 | 3 | 4 | Score | Status |
| Buffalo Bills | 3 | 16 | 21 | 0 | 40 | |
| Carolina Panthers | 0 | 3 | 0 | 6 | 9 | Final |
| Scoring Summary | |
| 1st Quarter | |
| Buffalo Bills field goal. Matt Prater 45 Yd Field Goal | |
| 2nd Quarter | |
| Buffalo Bills field goal. Matt Prater 43 Yd Field Goal | |
| Carolina Panthers field goal. Ryan Fitzgerald 48 Yd Field Goal | |
| Buffalo Bills touchdown. James Cook III 64 Yd Rush (Matt Prater PAT Failed) | |
| Buffalo Bills touchdown. Josh Allen 1 Yd Run (Matt Prater Kick) | |
| 3rd Quarter | |
| Buffalo Bills touchdown. Khalil Shakir 54 Yd pass from Josh Allen (Matt Prater Kick) | |
| Buffalo Bills touchdown. James Cook III 21 Yd Rush (Matt Prater Kick) | |
| Buffalo Bills touchdown. Josh Allen 1 Yd Rush (Matt Prater Kick) | |
| 4th Quarter | |
| Carolina Panthers touchdown. Chuba Hubbard 3 Yd Rush (Ryan Fitzgerald PAT Failed) | |
| Team stats | ||
| First down | Buffalo Bills | Carolina Panthers |
| Total first downs | 23 | 19 |
| First downs from rushing | 12 | 5 |
| First downs from passing | 10 | 11 |
| First downs from penalties | 1 | 3 |
| Third down | Buffalo Bills | Carolina Panthers |
| Third downs attempted | 12 | 11 |
| Third downs converted | 7 | 4 |
| Third down percentage | 58 % | 36 % |
| Fourth down | Buffalo Bills | Carolina Panthers |
| Fourth downs attempted | 0 | 0 |
| Fourth downs converted | 0 | 0 |
| Fourth down percentage | 0 % | 0 % |
| Offense | Buffalo Bills | Carolina Panthers |
| Total yards | 410 | 244 |
| Total rushing yards | 245 | 114 |
| Total passing yards | 165 | 130 |
| Total offensive plays | 60 | 59 |
| Average yards per play | 6.8 | 4.1 |
| Time of possession | 33:32 | 26:28 |
| Rushing | Buffalo Bills | Carolina Panthers |
| Total rushing plays | 35 | 28 |
| Total rushing yards | 245 | 114 |
| Average yards per rush | 7.0 | 4.1 |
| Rushing touchdowns | 4 | 1 |
| Passing | Buffalo Bills | Carolina Panthers |
| Passes attempted | 0 | 0 |
| Passes completed | 0 | 0 |
| Average yards per completion | 6.6 | 4.2 |
| Passing touchdowns | 1 | 0 |
| Penalties | Buffalo Bills | Carolina Panthers |
| Penalties committed | 7 | 4 |
| Penalty yards | 60 | 20 |
| Turnovers | Buffalo Bills | Carolina Panthers |
| Passes intercepted | 0 | 1 |
| Interception returns | 0 | 1 |
| Interception return yards | ||
| Fumbles | ||
| Fumbles lost | 0 | 2 |
| Rushing | |||||||||
| Buffalo Bills | Rushes | Yards | Yards/rush | TD | Long | ||||
| James Cook III | 19 | 216 | 11.4 | 2 | 64 | ||||
| Ray Davis | 9 | 16 | 1.8 | 0 | 5 | ||||
| Josh Allen | 3 | 7 | 2.3 | 2 | 5 | ||||
| Ty Johnson | 4 | 6 | 1.5 | 0 | 4 | ||||
| Carolina Panthers | Rushes | Yards | Yards/rush | TD | Long | ||||
| Rico Dowdle | 8 | 54 | 6.8 | 0 | 24 | ||||
| Chuba Hubbard | 12 | 34 | 2.8 | 1 | 5 | ||||
| Trevor Etienne | 4 | 16 | 4.0 | 0 | 8 | ||||
| Jimmy Horn Jr. | 2 | 9 | 4.5 | 0 | 7 | ||||
| Andy Dalton | 2 | 1 | 0.5 | 0 | 1 | ||||
| Passing | |||||||||
| Buffalo Bills | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Josh Allen | 19 | 12 | 63 % | 163 | 8.6 | 1 | 0 | 2-20 | 46.3 |
| Mitchell Trubisky | 4 | 2 | 50 % | 22 | 5.5 | 0 | 0 | 0-0 | 88.0 |
| Carolina Panthers | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Andy Dalton | 24 | 16 | 67 % | 175 | 7.3 | 0 | 1 | 7-45 | 4.2 |
| Receiving | |||||||||
| Buffalo Bills | Catches | Yards | Yards/catch | TD | Long | ||||
| Khalil Shakir | 6 | 88 | 14.7 | 1 | 54 | ||||
| Keon Coleman | 3 | 30 | 10.0 | 0 | 14 | ||||
| Dalton Kincaid | 1 | 23 | 23.0 | 0 | 23 | ||||
| Dawson Knox | 1 | 15 | 15.0 | 0 | 15 | ||||
| Jackson Hawes | 2 | 15 | 7.5 | 0 | 12 | ||||
| Elijah Moore | 1 | 14 | 14.0 | 0 | 14 | ||||
| Ray Davis | 0 | 0 | 0.0 | 0 | 0 | ||||
| Carolina Panthers | Catches | Yards | Yards/catch | TD | Long | ||||
| Tetairoa McMillan | 7 | 99 | 14.1 | 0 | 19 | ||||
| Jalen Coker | 3 | 36 | 12.0 | 0 | 22 | ||||
| Ja'Tavion Sanders | 3 | 19 | 6.3 | 0 | 9 | ||||
| Xavier Legette | 2 | 17 | 8.5 | 0 | 11 | ||||
| Tommy Tremble | 1 | 4 | 4.0 | 0 | 4 | ||||
| Chuba Hubbard | 0 | 0 | 0.0 | 0 | 0 | ||||
| Jimmy Horn Jr. | 0 | 0 | 0.0 | 0 | 0 | ||||
| Fumbles | |||||||||
| Buffalo Bills | Lost | Recovered | Total | ||||||
| Christian Benford | 0 | 1 | 0 | ||||||
| Deone Walker | 0 | 1 | 0 | ||||||
| Carolina Panthers | Lost | Recovered | Total | ||||||
| Andy Dalton | 2 | 1 | 2 | ||||||
| Austin Corbett | 0 | 0 | 1 | ||||||
| Interceptions | |||||||||
| Buffalo Bills | Total | Yards | Int TDs | ||||||
| AJ Epenesa | 1 | 24 | 0 | ||||||
| Carolina Panthers | Total | Yards | Int TDs | ||||||
| None | |||||||||
| Defense | |||||||||
| Buffalo Bills | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Dorian Williams | 8 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Cole Bishop | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Joe Andreessen | 7 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jordan Hancock | 5 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jordan Poyer | 5 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| AJ Epenesa | 4 | 3 | 1 | 1 | 1 | 0 | 0 | 0 | |
| Shaq Thompson | 4 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Taron Johnson | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Greg Rousseau | 3 | 3 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Cam Lewis | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ed Oliver | 3 | 2 | 2 | 0 | 2 | 0 | 0 | 0 | |
| Christian Benford | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Michael Hoecht | 3 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Larry Ogunjobi | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Joey Bosa | 2 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | |
| Javon Solomon | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Reggie Gilliam | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Deone Walker | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Jordan Phillips | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Tre'Davious White | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ja'Marcus Ingram | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Maxwell Hairston | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Carolina Panthers | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Christian Rozeboom | 12 | 7 | 2 | 1 | 0 | 0 | 0 | 0 | |
| Nick Scott | 8 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Trevin Wallace | 7 | 5 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Nic Scourton | 5 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Tershawn Wharton | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tre'von Moehrig | 4 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jaycee Horn | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Chau Smith-Wade | 3 | 2 | 0 | 1 | 0 | 0 | 0 | 0 | |
| A'Shawn Robinson | 3 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | |
| D.J. Wonnum | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Thomas Incoom | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Claudin Cherelus | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Boogie Basham | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Corey Thornton | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Bobby Brown III | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Mike Jackson | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Rico Dowdle | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Chuba Hubbard | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Lathan Ransom | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Ja'Tavion Sanders | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Andy Dalton | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Derrick Brown | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Akayleb Evans | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Brady Christensen | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Brycen Tremayne | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Bam Martin-Scott | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kick returns | |||||||||
| Buffalo Bills | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| Curtis Samuel | 1 | 23 | 23.0 | 23 | 0 | ||||
| Ty Johnson | 1 | 21 | 21.0 | 21 | 0 | ||||
| Carolina Panthers | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| Trevor Etienne | 4 | 100 | 25.0 | 27 | 0 | ||||
| Rico Dowdle | 1 | 29 | 29.0 | 29 | 0 | ||||
| Chuba Hubbard | 1 | 27 | 27.0 | 27 | 0 | ||||
| Punt returns | |||||||||
| Buffalo Bills | Total | Yards | Avg | Long | TD | ||||
| Khalil Shakir | 2 | 8 | 4.0 | 4 | 0 | ||||
| Keon Coleman | 1 | 6 | 6.0 | 6 | 0 | ||||
| Carolina Panthers | Total | Yards | Avg | Long | TD | ||||
| Trevor Etienne | 2 | 13 | 6.5 | 7 | 0 | ||||
| Kicking | |||||||||
| Buffalo Bills | FG | Long | Extra Pt | Points | |||||
| Matt Prater | 2/2 | 45 | 4/5 | 10 | |||||
| Carolina Panthers | FG | Long | Extra Pt | Points | |||||
| Ryan Fitzgerald | 1/2 | 48 | 0/1 | 3 | |||||
| Punting | |||||||||
| Buffalo Bills | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Mitch Wishnowsky | 3 | 146 | 48.7 | 0 | 2 | 54 | |||
| Carolina Panthers | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Sam Martin | 4 | 211 | 52.8 | 0 | 1 | 60 | |||
Last updated on Tuesday, October 28, 2025 2:20 AM.