San Francisco 49ers at Arizona Cardinals
| Team | 1 | 2 | 3 | 4 | Score | Status |
| San Francisco 49ers | 0 | 0 | 7 | 3 | 10 | |
| Arizona Cardinals | 7 | 3 | 0 | 7 | 17 | Final |
| Scoring Summary | |
| 1st Quarter | |
| 9:02 | Arizona Cardinals touchdown. James Conner 1 Yd Run (Matt Prater Kick) |
| 2nd Quarter | |
| 5:27 | Arizona Cardinals field goal. Matt Prater 21 Yd Field Goal |
| 3rd Quarter | |
| 1:42 | San Francisco 49ers touchdown. Deebo Samuel 13 Yd Run (Joey Slye Kick) |
| 4th Quarter | |
| 5:13 | Arizona Cardinals touchdown. DeAndre Hopkins 9 Yd pass from Kyler Murray (Matt Prater Kick) |
| 4:12 | San Francisco 49ers field goal. Joey Slye 47 Yd Field Goal |
| Team stats | ||
| First down | San Francisco 49ers | Arizona Cardinals |
| Total first downs | 19 | 20 |
| First downs from rushing | 7 | 8 |
| First downs from passing | 9 | 11 |
| First downs from penalties | 3 | 1 |
| Third down | San Francisco 49ers | Arizona Cardinals |
| Third downs attempted | 11 | 10 |
| Third downs converted | 3 | 3 |
| Third down percentage | 27 % | 30 % |
| Fourth down | San Francisco 49ers | Arizona Cardinals |
| Fourth downs attempted | 5 | 0 |
| Fourth downs converted | 1 | 0 |
| Fourth down percentage | 20 % | 0 % |
| Offense | San Francisco 49ers | Arizona Cardinals |
| Total yards | 338 | 304 |
| Total rushing yards | 152 | 94 |
| Total passing yards | 186 | 210 |
| Total offensive plays | 59 | 60 |
| Average yards per play | 9 | 10 |
| Time of possession | 31:54 | 28:06 |
| Rushing | San Francisco 49ers | Arizona Cardinals |
| Total rushing plays | 28 | 27 |
| Total rushing yards | 152 | 94 |
| Average yards per rush | 5.4 | 3.5 |
| Rushing touchdowns | 1 | 1 |
| Passing | San Francisco 49ers | Arizona Cardinals |
| Passes attempted | 29 | 31 |
| Passes completed | 15 | 22 |
| Average yards per completion | 6.0 | 6.4 |
| Passing touchdowns | 0 | 1 |
| Penalties | San Francisco 49ers | Arizona Cardinals |
| Penalties committed | 7 | 6 |
| Penalty yards | 60 | 62 |
| Turnovers | San Francisco 49ers | Arizona Cardinals |
| Passes intercepted | 1 | 0 |
| Interception returns | 1 | 0 |
| Interception return yards | ||
| Fumbles | ||
| Fumbles lost | 0 | 1 |
| Rushing | |||||||||
| San Francisco 49ers | Rushes | Yards | Yards/rush | TD | Long | ||||
| Trey Lance | 16 | 89 | 5.6 | 0 | 15 | ||||
| Elijah Mitchell | 9 | 43 | 4.8 | 0 | 14 | ||||
| Deebo Samuel | 1 | 13 | 13.0 | 1 | 13 | ||||
| Trey Sermon | 1 | 7 | 7.0 | 0 | 7 | ||||
| Kyle Juszczyk | 1 | 0 | 0.0 | 0 | 0 | ||||
| Arizona Cardinals | Rushes | Yards | Yards/rush | TD | Long | ||||
| Rondale Moore | 3 | 38 | 12.7 | 0 | 26 | ||||
| James Conner | 10 | 29 | 2.9 | 1 | 8 | ||||
| Chase Edmonds | 6 | 15 | 2.5 | 0 | 5 | ||||
| Christian Kirk | 1 | 11 | 11.0 | 0 | 11 | ||||
| Kyler Murray | 7 | 1 | 0.1 | 0 | 10 | ||||
| Passing | |||||||||
| San Francisco 49ers | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Trey Lance | 29 | 15 | 52 % | 192 | 6.6 | 0 | 1 | 2-6 | 33.9 |
| Arizona Cardinals | Att | Comp | Comp % | Yards | Yards/pass | TD | Int | Sacks/Yards | QB Rating |
| Kyler Murray | 31 | 22 | 71 % | 239 | 7.7 | 1 | 0 | 2-29 | 32.7 |
| Receiving | |||||||||
| San Francisco 49ers | Catches | Yards | Yards/catch | TD | Long | ||||
| Deebo Samuel | 3 | 58 | 19.3 | 0 | 26 | ||||
| Kyle Juszczyk | 3 | 35 | 11.7 | 0 | 18 | ||||
| Brandon Aiyuk | 2 | 32 | 16.0 | 0 | 26 | ||||
| Ross Dwelley | 2 | 25 | 12.5 | 0 | 13 | ||||
| Mohamed Sanu Sr. | 2 | 19 | 9.5 | 0 | 13 | ||||
| Elijah Mitchell | 2 | 19 | 9.5 | 0 | 14 | ||||
| Charlie Woerner | 1 | 4 | 4.0 | 0 | 4 | ||||
| Travis Benjamin | 0 | 0 | 0.0 | 0 | 0 | ||||
| Arizona Cardinals | Catches | Yards | Yards/catch | TD | Long | ||||
| DeAndre Hopkins | 6 | 87 | 14.5 | 1 | 30 | ||||
| Rondale Moore | 5 | 59 | 11.8 | 0 | 33 | ||||
| Christian Kirk | 5 | 39 | 7.8 | 0 | 9 | ||||
| Chase Edmonds | 3 | 19 | 6.3 | 0 | 10 | ||||
| Maxx Williams | 1 | 14 | 14.0 | 0 | 14 | ||||
| A.J. Green | 1 | 13 | 13.0 | 0 | 13 | ||||
| James Conner | 1 | 8 | 8.0 | 0 | 8 | ||||
| Fumbles | |||||||||
| San Francisco 49ers | Lost | Recovered | Total | ||||||
| Dontae Johnson | 0 | 1 | 0 | ||||||
| Arizona Cardinals | Lost | Recovered | Total | ||||||
| Kyler Murray | 0 | 1 | 2 | ||||||
| Chase Edmonds | 1 | 1 | 1 | ||||||
| Andy Lee | 0 | 1 | 1 | ||||||
| Interceptions | |||||||||
| San Francisco 49ers | Total | Yards | Int TDs | ||||||
| None | |||||||||
| Arizona Cardinals | Total | Yards | Int TDs | ||||||
| Budda Baker | 1 | 17 | 0 | ||||||
| Defense | |||||||||
| San Francisco 49ers | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Fred Warner | 9 | 7 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jimmie Ward | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jaquiski Tartt | 7 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Josh Norman | 6 | 3 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Nick Bosa | 5 | 4 | 2 | 0 | 2 | 0 | 0 | 0 | |
| Emmanuel Moseley | 5 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | |
| D.J. Jones | 4 | 4 | 1 | 0 | 1 | 0 | 0 | 0 | |
| Dontae Johnson | 3 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Marcell Harris | 3 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | |
| Azeez Al-Shaair | 3 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Samson Ebukam | 2 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Arik Armstead | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Maurice Hurst | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ross Dwelley | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Trenton Cannon | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Kentavius Street | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Arden Key | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Arizona Cardinals | Tackles | Unassist. tkl | TFL | Pass def. | QB hits | Int TD | K blocked | K ret. TD | |
| Jalen Thompson | 6 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Budda Baker | 6 | 5 | 0 | 1 | 0 | 0 | 0 | 0 | |
| Jordan Hicks | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Antonio Hamilton | 6 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Zach Allen | 5 | 4 | 2 | 0 | 1 | 0 | 0 | 0 | |
| Zaven Collins | 4 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| J.J. Watt | 3 | 3 | 2 | 1 | 4 | 0 | 0 | 0 | |
| Markus Golden | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jace Whittaker | 3 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Isaiah Simmons | 3 | 2 | 0 | 1 | 1 | 0 | 0 | 0 | |
| Robert Alford | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Ezekiel Turner | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Rashard Lawrence | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Tanner Vallejo | 2 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | |
| Devon Kennard | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Jonathan Ward | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Eno Benjamin | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| Leki Fotu | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | |
| Kick returns | |||||||||
| San Francisco 49ers | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| None | |||||||||
| Arizona Cardinals | Total | Yards | Avg | Long | TD | Kick ret. TD | |||
| None | |||||||||
| Punt returns | |||||||||
| San Francisco 49ers | Total | Yards | Avg | Long | TD | ||||
| Brandon Aiyuk | 2 | 6 | 3.0 | 5 | 0 | ||||
| Arizona Cardinals | Total | Yards | Avg | Long | TD | ||||
| Rondale Moore | 1 | 12 | 12.0 | 12 | 0 | ||||
| Kicking | |||||||||
| San Francisco 49ers | FG | Long | Extra Pt | Points | |||||
| Joey Slye | 1/1 | 47 | 1/1 | 4 | |||||
| Arizona Cardinals | FG | Long | Extra Pt | Points | |||||
| Matt Prater | 1/2 | 21 | 2/2 | 5 | |||||
| Punting | |||||||||
| San Francisco 49ers | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Mitch Wishnowsky | 2 | 97 | 48.5 | 0 | 1 | 58 | |||
| Arizona Cardinals | Total | Yards | Avg | Touchbacks | Inside 20 | Long | |||
| Andy Lee | 4 | 205 | 51.3 | 1 | 1 | 56 | |||
Last updated on Wednesday, October 13, 2021 8:04 PM.